Manchester United became the first Premier League side to lose three semi-finals in one season with their defeat to Sevilla in the Europa League.
Spanish side come from behind to sink Ole Gunnar Solskjaer’s men in Cologne.
The Ukrainian champions are unbeaten in 11 games in all competitions.
Five-time Europa League winners Sevilla have proved the scourge of English clubs in recent years.
The teams go head to head in Cologne on Sunday evening.
United edged past FC Copenhagen in Cologne in the quarter-final on Monday.
Manchester United face Sevilla in the semi-finals on Sunday.
United lost in the semi-finals of both domestic cup competitions this season.
Lucas Ocampos’ late header saw the Spanish side dump Wolves out of the Europa League on Tuesday evening.
Bruno Fernandes’ extra-time penalty saw Ole Gunnar Solskjaer’s team scrape past FC Copenhagen in Cologne on Monday evening.
The Red Devils have already fallen in the final four of the Carabao Cup and FA Cup.
Ole Gunnar Solskjaer’s side had an overturned penalty, two disallowed goals and efforts off the woodwork.
The Spanish side are unbeaten in 11 matches since lockdown.
United face FC Copenhagen in Cologne on Monday night.
Manchester United take on Copenhagen in the last eight on Monday.
