Guernsey scored six tries to claim a bonus point and move nine points clear of Worthing, who are directly below them in the table.
Charlie Simmonds set the ball rolling with a try in the opening couple of minutes before Ciaran McGann, Charlie Currie and Anthony Armstrong also touched down in the first half to earn the four-try bonus point.
After the interval, Armstrong got his second of the match and Hugo Culverhouse continued his fine run of form with Guernsey's final try.
McGann also added nine points with the boot.
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