The move has been welcomed by charity Age Concern, which said that some members had limited access to transport.
Prior to Saturday, when wearing face coverings on public transport and in public spaces became mandatory, these journeys were not considered essential.
If journeys are not essential, islanders are asked to stay home and stay safe.
‘CT Plus was following the States’ advice not to allow any passengers to use the buses either going to their Covid vaccination appointment or returning,’ a CT Plus spokesman said.
‘Upon further discussion, the advice has since been reviewed and we can confirm that buses can now take any passenger travelling to and from their vaccine appointments.’
Many islanders rely on the bus service for travel.
Age Concern chairman David Inglis welcomed the move.
‘This is great news and seems to be in response to helping our members who have limited access to transport,’ he said.
‘CT Plus has always been supportive of members’ particular needs so this is a welcome helping hand during a difficult stage in delivering and administering the vaccination to those in need.’
Face coverings must be worn at all times on buses unless the person has a valid reason for exemption.
Some bus drivers may be exempt from wearing coverings, but follow all other safety requirements to protect the community.
Social distancing is used when boarding buses with only non-cash payments being taken, including Puffin cards, contactless cards, concession and student cards.
. Call CT Plus on 700456 with any queries. Opening hours are 8am until 6pm Monday to Saturday and 10am to 4pm on Sundays.